Gene
Synonyms
DUET DUO HAPIP TRAD
Protein Name
Kalirin
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
3,40,174
Protein Length
2,985
Protein Domain
3D Structure
(PDB ID : N/A)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + a protein = ADP + a phosphoprotein.
Localization
Cytoplasm Cytoplasm, cytoskeleton Note=Associated with the cytoskeleton.
Function
Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.
Gene Ontology
GO:0004674; GO:0005085; GO:0005089; GO:0005096; GO:0005524; GO:0005654; GO:0005829; GO:0006468; GO:0007165; GO:0007186; GO:0007399; GO:0007528; GO:0007595; GO:0007613; GO:0008344; GO:0015629; GO:0016192; GO:0035023; GO:0035176; GO:0035556; GO:0042711; GO:0043065; GO:0046872; GO:0046959; GO:0048013; GO:0051056; GO:0060125; GO:0060137; GO:0061003; GO:0070062
