Protein Name
Calcium/calmodulin-dependent protein kinase kinase 2
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
64,446
Protein Length
587
Protein Domain
3D Structure
(PDB ID : N/A)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + a protein = ADP + a phosphoprotein.
Localization
Nucleus. Cytoplasm. Cell projection. Note=Predominantly nuclear in unstimulated cells. Found in the cytoplasm or neurites and forskolin induction.
Function
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1 and CAMK4. Phosphorylates CAMK1D (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals. May play a role in neurite growth. Isoform 2 may promote neurite elongation, while isoform 1 may promoter neurite branching.
Gene Ontology
GO:0004672; GO:0004683; GO:0005509; GO:0005516; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0030295; GO:0032147; GO:0042995; GO:0046777
