STRING | IntAct | MINT

Open Targets | OMIM

ATP + a protein = ADP + a phosphoprotein.; ATP + [tau protein] = ADP + [tau protein] phosphate.

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, perinuclear region Endoplasmic reticulum Note=Detected at centrosomes during mitosis. Localizes to the endoplasmic reticulum in response to stress caused by tunicamycin (By similarity).

Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-504' and 'Ser-554'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-175 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-261 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress.

GO:0000086; GO:0000287; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005783; GO:0005813; GO:0006468; GO:0006887; GO:0007409; GO:0010975; GO:0018105; GO:0019901; GO:0030010; GO:0030182; GO:0031532; GO:0035556; GO:0036503; GO:0048471; GO:0048812; GO:0050321; GO:0050770; GO:0051117; GO:0051301; GO:0061178; GO:0070059; GO:0090176; GO:0150034