CaMKipedia | Result

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer

Gene

TTN

Synonyms

N/A

Protein Name

Titin

UniProt ID

Q8WZ42

Ensembl Gene ID

9606.ENSP00000343764

NCBI Gene ID

7273

Molecular Weight

38,16,030

Protein Length

34,350

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1tki)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.1 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + a protein = ADP + a phosphoprotein.

Localization

Cytoplasm Nucleus

Function

Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.

Gene Ontology

GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0010628; GO:0010737; GO:0019899; GO:0019901; GO:0030017; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050714; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493

Gene Ontology

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
TCAP (O15273)	Homo sapiens	S157	GALRRSLSRSMSQEA	0.25	0.6906	TP	certain	experimental	31 \| 143 \|	9804419	-	-
Tcap (O70548)	Mus musculus	S157	GPLRRTLSRSMSQEA	-	0.7459	-	-	-	-	-	-	In vitro
TCAP (A2TDC0)	Homo sapiens	S157	GALRRSLSRSMSQEA	-	0.6906	-	-	-	-	-	-	-
MYLPF (A0A024QZG6)	Homo sapiens	S16	RTVEGGSSSVFSMFD	-	0.4582	-	-	-	-	-	-	-
MYL9 (Q6IBG1)	Homo sapiens	S20	KRPQRATSNVFAMFD	-	0.5665	-	-	-	-	-	-	-
MYL9 (Q6IBG1)	Homo sapiens	T19	KKRPQRATSNVFAMF	-	0.5342	-	-	-	-	-	-	-

Kinase

Substrate

Interactor

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found