| Gene |
APAF1
|
| Protein Name |
APAF_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Apoptotic protease-activating factor 1 (APAF-1) |
| Protein Family |
N/A |
| NCBI Gene ID |
317
|
| UniProt ID |
O14727
|
| Enzyme Class |
- |
| Molecular Weight |
141840 |
| Protein Length |
1248 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. |
| Gene Ontology |
GO:0000166; GO:0001666; GO:0001822; GO:0001843; GO:0005524; GO:0005576; GO:0005634; GO:0005829; GO:0006915; GO:0006919; GO:0007399; GO:0007568; GO:0007584; GO:0008635; GO:0008656; GO:0010659; GO:0030154; GO:0030900; GO:0031072; GO:0032991; GO:0034774; GO:0042802; GO:0042981; GO:0043065; GO:0043293; GO:0043312; GO:0043531; GO:0051260; GO:0051402; GO:0070059; GO:0070062; GO:0070317; GO:0071560; GO:0072432; GO:0097193; GO:1902510; GO:1904813; GO:2001235 |
