| Gene |
KALRN
|
| Protein Name |
KALRN_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Kalirin (EC 2.7.11.1) (Huntingtin-associated protein-interacting protein) (Protein Duo) (Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
8997
|
| UniProt ID |
O60229
|
| Enzyme Class |
2.7.11.1 |
| Molecular Weight |
340174 |
| Protein Length |
2985 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a protein = ADP + a phosphoprotein. |
| Localization |
Cytoplasm Note=Associated with the cytoskeleton. |
| Function (UniProt annotation) |
Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. |
| Gene Ontology |
GO:0004674; GO:0005085; GO:0005089; GO:0005096; GO:0005524; GO:0005654; GO:0005829; GO:0006468; GO:0007165; GO:0007186; GO:0007399; GO:0007528; GO:0007595; GO:0007613; GO:0008344; GO:0015629; GO:0016192; GO:0035023; GO:0035176; GO:0035556; GO:0042711; GO:0043065; GO:0046872; GO:0046959; GO:0048013; GO:0051056; GO:0060125; GO:0060137; GO:0061003; GO:0070062 |
