CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	HBP1
Protein Name	HBP1_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	HMG box-containing protein 1 (HMG box transcription factor 1) (High mobility group box transcription factor 1)
Protein Family	N/A
NCBI Gene ID	26959
UniProt ID	O60381
Enzyme Class	-
Molecular Weight	57645
Protein Length	514
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Nucleus
Function (UniProt annotation)	Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.
Gene Ontology	GO:0000981; GO:0003677; GO:0003723; GO:0005654; GO:0007050; GO:0016055; GO:0016607

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PIM1 (P11309)	Homo sapiens	S380	MARQRRASLSCGGPG	0.862	0.4766	-	-	-	-	-	-	in-vitro and in-vivo
PIM1 (P11309)	Homo sapiens	S372	SAVYVLSSMARQRRA	0.761	0.2817	-	-	-	-	-	-	in-vitro and in-vivo

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found