CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	Ulk1
Protein Name	ULK1_MOUSE
Organism	Mus musculus (Mouse)
Alternative name(s)	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Serine/threonine-protein kinase Unc51.1) (Unc-51-like kinase 1)
Protein Family	Protein kinase superfamily
NCBI Gene ID	22241
UniProt ID	O70405
Enzyme Class	2.7.11.1
Molecular Weight	112463
Protein Length	1051
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	ATP + a protein = ADP + a phosphoprotein.
Localization	Cytoplasm, cytosol Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome.
Function (UniProt annotation)	Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165).
Gene Ontology	GO:0000045; GO:0000407; GO:0000423; GO:0004672; GO:0004674; GO:0005524; GO:0005737; GO:0005776; GO:0005829; GO:0006914; GO:0007265; GO:0007409; GO:0008104; GO:0010468; GO:0010506; GO:0010941; GO:0016020; GO:0016236; GO:0017137; GO:0018105; GO:0018107; GO:0019901; GO:0021707; GO:0021933; GO:0030424; GO:0030659; GO:0031102; GO:0031175; GO:0031333; GO:0031623; GO:0031669; GO:0034045; GO:0034198; GO:0042594; GO:0042802; GO:0043005; GO:0043025; GO:0044877; GO:0046777; GO:0048671; GO:0048675; GO:0051020; GO:0051386; GO:0051879; GO:0075044; GO:0097629; GO:0097632; GO:0097635; GO:0098780; GO:1990316; GO:2000786

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
Prkaa1 (Q5EG47)	Mus musculus	S467	SAIRRSGSTTPLGFG	N/A	0.7505	TP	certain	experimental	72 \| 9 \| 55 \| 30 \|	21205641	-	-
Prkaa1 (Q5EG47)	Mus musculus	S555	GLGCRLHSAPNLSDF	N/A	0.5254	TP	certain	experimental	72 \| 9 \| 55 \| 30 \|	21205641	-	-
Prkaa1 (Q5EG47)	Mus musculus	S637	FDFPKTPSSQNLLTL	N/A	0.5707	TP	certain	experimental	30 \|	21205641	-	-
Prkaa1 (Q5EG47)	Mus musculus	T574	PKLPKPPTDPLGATF	N/A	0.8343	TP	certain	experimental	30 \|	21205641	-	-
PRKAA1 (Q13131)	Homo sapiens	S467	SAIRRSGSTTPLGFG	N/A	0.7505	-	-	-	-	-	-	In vitro and in vivo
PRKAA1 (Q13131)	Homo sapiens	S555	GLGCRLHSAPNLSDF	N/A	0.5254	-	-	-	-	-	-	In vitro and in vivo
PRKAA1 (Q13131)	Homo sapiens	S317	SHLASPPSLGEMPQL	N/A	0.7718	-	-	-	-	-	-	in-vitro and in-vivo
PRKAA1 (Q13131)	Homo sapiens	S777	TRMFSVGSSSSLGST	N/A	0.6089	-	-	-	-	-	-	in-vitro and in-vivo

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
mmu04140	Regulation of autophagy
mmu04150	mTOR signaling pathway

No NCI Nature pathways found