| Gene |
PIAS1
|
| Protein Name |
PIAS1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein) |
| Protein Family |
PIAS family |
| NCBI Gene ID |
8554
|
| UniProt ID |
O75925
|
| Enzyme Class |
2.3.2.- |
| Molecular Weight |
71836 |
| Protein Length |
651 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus speckle Note=Interaction with CSRP2 may induce a partial redistribution along the cytoskeleton. |
| Function (UniProt annotation) |
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity). |
| Gene Ontology |
GO:0000082; GO:0000122; GO:0003677; GO:0003713; GO:0003714; GO:0005634; GO:0005654; GO:0007259; GO:0007283; GO:0008022; GO:0008270; GO:0008542; GO:0016605; GO:0016607; GO:0016925; GO:0019789; GO:0019899; GO:0019904; GO:0030521; GO:0031625; GO:0032436; GO:0033235; GO:0042127; GO:0043066; GO:0045444; GO:0045893; GO:0050681; GO:0051152; GO:0060334; GO:0061665; GO:0065004 |
