| Gene |
KIF4A
|
| Protein Name |
KIF4A_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Chromosome-associated kinesin KIF4A (Chromokinesin-A) |
| Protein Family |
TRAFAC class myosin-kinesin ATPase superfamily |
| NCBI Gene ID |
24137
|
| UniProt ID |
O95239
|
| Enzyme Class |
- |
| Molecular Weight |
139881 |
| Protein Length |
1232 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus matrix. Cytoplasm, cytoskeleton, spindle. Midbody. Chromosome. Note=Not present in the nucleolus. In early mitosis, associated with the mitotic spindle, in anaphase, localized to the spindle midzone and, in telophase and cytokinesis, to the midbody. In late cytokinesis, found in the center of the midbody. Associated with chromosomes at all stages of mitosis. |
| Function (UniProt annotation) |
Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization. |
| Gene Ontology |
GO:0000281; GO:0003677; GO:0003777; GO:0005524; GO:0005654; GO:0005694; GO:0005737; GO:0005829; GO:0005871; GO:0005874; GO:0005876; GO:0006890; GO:0006996; GO:0007018; GO:0007052; GO:0008017; GO:0008089; GO:0016020; GO:0016363; GO:0016887; GO:0019886; GO:0030496; GO:0045171; GO:0051256; GO:1904115 |
