| Gene |
PARN
|
| Protein Name |
PARN_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate-specific ribonuclease) |
| Protein Family |
CAF1 family |
| NCBI Gene ID |
5073
|
| UniProt ID |
O95453
|
| Enzyme Class |
3.1.13.4 |
| Molecular Weight |
73451 |
| Protein Length |
639 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
Exonucleolytic cleavage of poly(A) to 5'-AMP. |
| Localization |
Nucleus Note=Some nuclear fraction is nucleolar. |
| Function (UniProt annotation) |
3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (PubMed:10882133, PubMed:11359775, PubMed:12748283, PubMed:15175153, PubMed:9736620). Also able to recognize and trim poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability (PubMed:25049417, PubMed:22442037). |
| Gene Ontology |
GO:0000175; GO:0000184; GO:0000289; GO:0000495; GO:0003723; GO:0003730; GO:0004518; GO:0004535; GO:0005634; GO:0005730; GO:0005737; GO:0005829; GO:0007292; GO:0009451; GO:0010587; GO:0019901; GO:0032212; GO:0043169; GO:0043488; GO:0046872; GO:0051973; GO:0070034; GO:0071051; GO:0090503; GO:0090669; GO:0110008; GO:1904872 |
