CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	BAG2
Protein Name	BAG2_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	BAG family molecular chaperone regulator 2 (BAG-2) (Bcl-2-associated athanogene 2)
Protein Family	N/A
NCBI Gene ID	9532
UniProt ID	O95816
Enzyme Class	-
Molecular Weight	23772
Protein Length	211
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	N/A
Function (UniProt annotation)	Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release (PubMed:24318877, PubMed:9873016).
Gene Ontology	GO:0000774; GO:0005829; GO:0006457; GO:0010954; GO:0019538; GO:0030424; GO:0030425; GO:0031072; GO:0031397; GO:0031625; GO:0032091; GO:0042802; GO:0044325; GO:0048156; GO:0050821; GO:0051087; GO:0101031; GO:1900034; GO:1901588; GO:1901800; GO:1904667

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
MAPKAPK2 (P49137)	Homo sapiens	S20	GRFCRSSSMADRSSR	0.053	0.4864	TP	certain	experimental	45 \| 148 \| 9 \| 55 \| 140 \|	15271996	-	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04141	Protein processing in endoplasmic reticulum

No NCI Nature pathways found