| Gene |
EIF2S1
|
| Protein Name |
IF2A_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) |
| Protein Family |
EIF-2-alpha family |
| NCBI Gene ID |
1965
|
| UniProt ID |
P05198
|
| Enzyme Class |
- |
| Molecular Weight |
36112 |
| Protein Length |
315 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm, Stress granule |
| Function (UniProt annotation) |
Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. |
| Gene Ontology |
GO:0003723; GO:0003743; GO:0005634; GO:0005829; GO:0005844; GO:0005850; GO:0005851; GO:0006413; GO:0007568; GO:0010494; GO:0016020; GO:0032057; GO:0033290; GO:0034063; GO:0034198; GO:0034599; GO:0034605; GO:0034644; GO:0034976; GO:0036499; GO:0043022; GO:0043614; GO:0044207; GO:0045202; GO:0046777; GO:0055085; GO:0070062; GO:0097451; GO:1901216; GO:1905098; GO:1990737; GO:2000676 |
