CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	FH
Protein Name	FUMH_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Fumarate hydratase, mitochondrial (Fumarase) (EC 4.2.1.2)
Protein Family	Class-II fumarase/aspartase family
NCBI Gene ID	2271
UniProt ID	P07954
Enzyme Class	4.2.1.2
Molecular Weight	54637
Protein Length	510
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	CATALYTIC ACTIVITY: (S)-malate = fumarate + H(2)O.
Localization	Isoform Mitochondrial: Mitochondrion.; Isoform Cytoplasmic: Cytoplasm.
Function (UniProt annotation)	Also acts as a tumor suppressor.
Gene Ontology	GO:0004333; GO:0005737; GO:0005739; GO:0005759; GO:0006099; GO:0006106; GO:0006108; GO:0045239; GO:0048873; GO:0070062; GO:0120162

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PRKAA1 (Q13131)	Homo sapiens	S75	YGAQTVRSTMNFKIG	0.781	0.2645	-	-	-	-	-	-	in-vitro and in-vivo

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found