| Gene |
TPM1
|
| Protein Name |
TPM1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1) |
| Protein Family |
Tropomyosin family |
| NCBI Gene ID |
7168
|
| UniProt ID |
P09493
|
| Enzyme Class |
- |
| Molecular Weight |
32709 |
| Protein Length |
284 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm, cytoskeleton |
| Function (UniProt annotation) |
Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. |
| Gene Ontology |
GO:0001701; GO:0001725; GO:0003065; GO:0003779; GO:0005200; GO:0005829; GO:0005856; GO:0005862; GO:0005884; GO:0006936; GO:0006937; GO:0007010; GO:0007015; GO:0008016; GO:0008092; GO:0008307; GO:0008360; GO:0015629; GO:0030017; GO:0030049; GO:0030336; GO:0031529; GO:0032059; GO:0032587; GO:0032781; GO:0034614; GO:0042060; GO:0042802; GO:0042803; GO:0045214; GO:0045785; GO:0046982; GO:0051015; GO:0051496; GO:0055010; GO:0060048; GO:1904706; GO:1904753 |
