| Gene |
AR
|
| Protein Name |
ANDR_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) |
| Protein Family |
Nuclear hormone receptor family |
| NCBI Gene ID |
367
|
| UniProt ID |
P10275
|
| Enzyme Class |
- |
| Molecular Weight |
99188 |
| Protein Length |
920 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus |
| Function (UniProt annotation) |
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. |
| Gene Ontology |
GO:0000122; GO:0000790; GO:0000978; GO:0000981; GO:0001077; GO:0001085; GO:0001091; GO:0001701; GO:0003073; GO:0003382; GO:0003677; GO:0003682; GO:0003700; GO:0004879; GO:0004882; GO:0005102; GO:0005496; GO:0005497; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0006351; GO:0006367; GO:0007165; GO:0007267; GO:0007283; GO:0007338; GO:0007548; GO:0008013; GO:0008134; GO:0008270; GO:0008283; GO:0008284; GO:0008285; GO:0010628; GO:0016579; GO:0016607; GO:0019102; GO:0019899; GO:0030521; GO:0030522; GO:0030850; GO:0032991; GO:0033148; GO:0033327; GO:0035264; GO:0042327; GO:0043410; GO:0043568; GO:0044212; GO:0045597; GO:0045720; GO:0045726; GO:0045893; GO:0045944; GO:0045945; GO:0046983; GO:0048638; GO:0048645; GO:0048808; GO:0050680; GO:0050790; GO:0051092; GO:0051117; GO:0051259; GO:0060520; GO:0060571; GO:0060599; GO:0060736; GO:0060740; GO:0060742; GO:0060748; GO:0060749; GO:0060769; GO:0070974; GO:0071383; GO:0071394; GO:0072520; GO:1903076; GO:2001237 |
