| Gene |
PABPC1
|
| Protein Name |
PABP1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) |
| Protein Family |
Polyadenylate-binding protein type-1 family |
| NCBI Gene ID |
26986
|
| UniProt ID |
P11940
|
| Enzyme Class |
- |
| Molecular Weight |
70671 |
| Protein Length |
636 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
Binds the poly(A) tail of mRNA, including that of its own transcript. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299). Positively regulates the replication of dengue virus (DENV) (PubMed:26735137). |
| Gene Ontology |
GO:0000184; GO:0000398; GO:0003723; GO:0003730; GO:0005634; GO:0005737; GO:0005829; GO:0005925; GO:0006378; GO:0006413; GO:0008022; GO:0008143; GO:0008266; GO:0008494; GO:0010494; GO:0016020; GO:0031047; GO:0036464; GO:0043488; GO:0045070; GO:0048255; GO:0060213; GO:0070062; GO:0071013; GO:1900153; GO:1990904; GO:2000623 |
