| Gene |
PKM
|
| Protein Name |
KPYM_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (p58) |
| Protein Family |
Pyruvate kinase family |
| NCBI Gene ID |
5315
|
| UniProt ID |
P14618
|
| Enzyme Class |
2.7.1.40 |
| Molecular Weight |
57937 |
| Protein Length |
531 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + pyruvate = ADP + phosphoenolpyruvate. |
| Localization |
Cytoplasm Nucleus. Note=Translocates to the nucleus in response to different apoptotic stimuli. Nuclear translocation is sufficient to induce cell death that is caspase independent, isoform-specific and independent of its enzymatic activity. |
| Function (UniProt annotation) |
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. |
| Gene Ontology |
GO:0000287; GO:0001666; GO:0001889; GO:0003723; GO:0004743; GO:0005524; GO:0005576; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0005929; GO:0006096; GO:0007584; GO:0009629; GO:0012501; GO:0014870; GO:0016301; GO:0023026; GO:0030955; GO:0031100; GO:0031982; GO:0032869; GO:0034774; GO:0042802; GO:0043209; GO:0043312; GO:0043403; GO:0043531; GO:0045296; GO:0051289; GO:0061621; GO:0062023; GO:0070062; GO:0070324; GO:1902912; GO:1903561; GO:1903672; GO:1904813 |
