| Gene |
Htr2a
|
| Protein Name |
5HT2A_RAT |
| Organism |
Rattus norvegicus (Rat) |
| Alternative name(s) |
5-hydroxytryptamine receptor 2A (5-HT-2) (5-HT-2A) (Serotonin receptor 2A) |
| Protein Family |
G-protein coupled receptor 1 family |
| NCBI Gene ID |
29595
|
| UniProt ID |
P14842
|
| Enzyme Class |
- |
| Molecular Weight |
52850 |
| Protein Length |
471 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cell membrane |
| Function (UniProt annotation) |
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction. |
| Gene Ontology |
GO:0001659; GO:0001965; GO:0004930; GO:0004993; GO:0005737; GO:0005829; GO:0005886; GO:0005887; GO:0005901; GO:0007186; GO:0007187; GO:0007200; GO:0007202; GO:0007204; GO:0007208; GO:0007268; GO:0007568; GO:0007613; GO:0008219; GO:0008284; GO:0010513; GO:0014059; GO:0014065; GO:0014824; GO:0014832; GO:0016020; GO:0019233; GO:0030424; GO:0030425; GO:0030431; GO:0030594; GO:0031410; GO:0042493; GO:0043025; GO:0043198; GO:0043267; GO:0043406; GO:0044380; GO:0044877; GO:0045600; GO:0045821; GO:0045907; GO:0048148; GO:0050731; GO:0050965; GO:0050966; GO:0051209; GO:0051378; GO:0051967; GO:0070374; GO:0070852; GO:0071886; GO:0098978; GO:0099055; GO:0099056; GO:2000300 |
