| Gene |
POU2F1
|
| Protein Name |
PO2F1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
POU domain, class 2, transcription factor 1 (NF-A1) (Octamer-binding protein 1) (Oct-1) (Octamer-binding transcription factor 1) (OTF-1) |
| Protein Family |
POU transcription factor family |
| NCBI Gene ID |
5451
|
| UniProt ID |
P14859
|
| Enzyme Class |
- |
| Molecular Weight |
76472 |
| Protein Length |
743 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus. |
| Function (UniProt annotation) |
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. |
| Gene Ontology |
GO:0000978; GO:0000979; GO:0000981; GO:0000983; GO:0003677; GO:0005634; GO:0005654; GO:0005783; GO:0019221; GO:0042795; GO:0043231; GO:0043565; GO:0045892; GO:0045944; GO:0090575 |
