| Gene |
HNRNPL
|
| Protein Name |
HNRPL_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Heterogeneous nuclear ribonucleoprotein L (hnRNP L) |
| Protein Family |
N/A |
| NCBI Gene ID |
3191
|
| UniProt ID |
P14866
|
| Enzyme Class |
- |
| Molecular Weight |
64133 |
| Protein Length |
589 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus, nucleoplasm |
| Function (UniProt annotation) |
Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). |
| Gene Ontology |
GO:0000381; GO:0000398; GO:0003723; GO:0003730; GO:0005634; GO:0005654; GO:0005829; GO:0006396; GO:0007623; GO:0016020; GO:0016070; GO:0034198; GO:0035770; GO:0044212; GO:0045120; GO:0045727; GO:0048025; GO:0048471; GO:0070062; GO:0097157; GO:1901652; GO:1902416; GO:1990715; GO:1990904 |
