| Gene |
BRAF
|
| Protein Name |
BRAF_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
673
|
| UniProt ID |
P15056
|
| Enzyme Class |
2.7.11.1 |
| Molecular Weight |
84437 |
| Protein Length |
766 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a protein = ADP + a phosphoprotein. |
| Localization |
Nucleus |
| Function (UniProt annotation) |
Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway. |
| Gene Ontology |
GO:0000165; GO:0002318; GO:0004672; GO:0004674; GO:0004709; GO:0005509; GO:0005524; GO:0005634; GO:0005739; GO:0005829; GO:0005886; GO:0006468; GO:0008542; GO:0009887; GO:0010628; GO:0010764; GO:0010828; GO:0030878; GO:0031434; GO:0033138; GO:0035019; GO:0035690; GO:0042127; GO:0042802; GO:0043005; GO:0043066; GO:0043231; GO:0043367; GO:0043369; GO:0043434; GO:0043524; GO:0044297; GO:0045580; GO:0046982; GO:0048538; GO:0048680; GO:0050772; GO:0050852; GO:0051291; GO:0051496; GO:0051591; GO:0060291; GO:0060323; GO:0060324; GO:0070374; GO:0070413; GO:0071277; GO:0090150; GO:1900026; GO:1990090; GO:2000301; GO:2000352 |
