| Gene |
Nme1
|
| Protein Name |
NDKA_MOUSE |
| Organism |
Mus musculus (Mouse) |
| Alternative name(s) |
Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Metastasis inhibition factor NM23) (NDPK-A) (Tumor metastatic process-associated protein) (nm23-M1) |
| Protein Family |
NDK family |
| NCBI Gene ID |
18102
|
| UniProt ID |
P15532
|
| Enzyme Class |
2.7.4.6 |
| Molecular Weight |
17208 |
| Protein Length |
152 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. |
| Localization |
Cytoplasm. Nucleus. |
| Function (UniProt annotation) |
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair (By similarity). |
| Gene Ontology |
GO:0000287; GO:0000977; GO:0002762; GO:0003697; GO:0004536; GO:0004550; GO:0005524; GO:0005525; GO:0005634; GO:0005739; GO:0005741; GO:0005813; GO:0005829; GO:0005882; GO:0006165; GO:0006183; GO:0006228; GO:0006241; GO:0006897; GO:0007595; GO:0010629; GO:0010976; GO:0014075; GO:0016020; GO:0019215; GO:0019899; GO:0019901; GO:0021766; GO:0030879; GO:0032587; GO:0033574; GO:0035690; GO:0042802; GO:0043015; GO:0043024; GO:0043209; GO:0043388; GO:0048471; GO:0050679; GO:0051591; GO:0071333; GO:0071398 |
