| Gene |
TCF3
|
| Protein Name |
TFE2_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1) |
| Protein Family |
N/A |
| NCBI Gene ID |
6929
|
| UniProt ID |
P15923
|
| Enzyme Class |
- |
| Molecular Weight |
67600 |
| Protein Length |
654 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus. |
| Function (UniProt annotation) |
Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region. |
| Gene Ontology |
GO:0000122; GO:0000790; GO:0000978; GO:0000981; GO:0001078; GO:0002326; GO:0003677; GO:0003700; GO:0003713; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0006351; GO:0006355; GO:0008134; GO:0016607; GO:0030183; GO:0030890; GO:0031435; GO:0032991; GO:0033152; GO:0035326; GO:0042803; GO:0043425; GO:0045666; GO:0045787; GO:0045893; GO:0045944; GO:0046982; GO:0051091; GO:0051149; GO:0070491; GO:0070644; GO:0070888; GO:0090575; GO:1902036; GO:2000045 |
