| Gene |
JAK1
|
| Protein Name |
JAK1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
3716
|
| UniProt ID |
P23458
|
| Enzyme Class |
2.7.10.2 |
| Molecular Weight |
133277 |
| Protein Length |
1154 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. |
| Localization |
Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated. |
| Function (UniProt annotation) |
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529). |
| Gene Ontology |
GO:0000165; GO:0004713; GO:0004715; GO:0005088; GO:0005131; GO:0005524; GO:0005634; GO:0005737; GO:0005768; GO:0005829; GO:0005856; GO:0005925; GO:0006468; GO:0016020; GO:0019221; GO:0019903; GO:0031625; GO:0031730; GO:0035556; GO:0035722; GO:0035723; GO:0038110; GO:0038111; GO:0038113; GO:0038114; GO:0046677; GO:0046872; GO:0060333; GO:0060334; GO:0060337; GO:0070102; GO:0070106; GO:0070757; GO:1903672 |
