CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	EIF4B
Protein Name	IF4B_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Eukaryotic translation initiation factor 4B (eIF-4B)
Protein Family	N/A
NCBI Gene ID	1975
UniProt ID	P23588
Enzyme Class	-
Molecular Weight	69151
Protein Length	611
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	N/A
Function (UniProt annotation)	Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
Gene Ontology	GO:0001731; GO:0002181; GO:0003723; GO:0003743; GO:0004386; GO:0005829; GO:0005844; GO:0006413; GO:0006446; GO:0016281; GO:0033592; GO:0034057; GO:0043024; GO:0097010

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PIM1 (P11309)	Homo sapiens	S406	RPRERHPSWRSEETQ	0.581	0.853	TP	certain	experimental	72 \| 9 \| 148 \| 28 \| 40 \| 55 \|	24777602	-	-
PIM2 (Q9P1W9)	Homo sapiens	S406	RPRERHPSWRSEETQ	0.581	0.853	TP	certain	experimental	40 \| 55 \| 9 \| 72 \| 9 \|	23749639	-	-
PIM2 (Q9P1W9)	Homo sapiens	S422	RERSRTGSESSQTGT	0.591	0.9488	TP	certain	experimental	40 \| 55 \| 9 \| 72 \| 9 \|	23749639	-	-
PIM1 (P11309)	Homo sapiens	S422	RERSRTGSESSQTGT	0.591	0.9488	TP	certain	experimental	40 \| 55 \| 9 \| 72 \| 9 \|	23749639	-	-
RPS6KA1 (Q15418)	Homo sapiens	S406	RPRERHPSWRSEETQ	0.581	0.853	-	-	-	-	-	-	-
RPS6KA1 (Q15418)	Homo sapiens	S422	RERSRTGSESSQTGT	0.591	0.9488	-	-	-	-	-	-	In vivo
MELK (Q14680)	Homo sapiens	S406	RPRERHPSWRSEETQ	0.581	0.853	-	-	-	-	-	-	in-vitro and in-vivo
MELK (Q14680)	Homo sapiens	S422	RERSRTGSESSQTGT	0.591	0.9488	-	-	-	-	-	-	in-vitro

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa03013	RNA transport
hsa04150	mTOR signaling pathway

No NCI Nature pathways found