| Gene |
DNAJB1
|
| Protein Name |
DNJB1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
DnaJ homolog subfamily B member 1 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 1) (HSP40) (Heat shock protein 40) (Human DnaJ protein 1) (hDj-1) |
| Protein Family |
N/A |
| NCBI Gene ID |
3337
|
| UniProt ID |
P25685
|
| Enzyme Class |
- |
| Molecular Weight |
38044 |
| Protein Length |
340 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm Note=Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock. |
| Function (UniProt annotation) |
Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). |
| Gene Ontology |
GO:0000122; GO:0001671; GO:0003714; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0006986; GO:0014069; GO:0030544; GO:0030900; GO:0032781; GO:0043025; GO:0043197; GO:0045296; GO:0051082; GO:0051085; GO:0051087; GO:0051117; GO:0061827; GO:0070062; GO:0090084; GO:0097201; GO:0098978; GO:1900034 |
