| Gene |
MARK3
|
| Protein Name |
MARK3_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
4140
|
| UniProt ID |
P27448
|
| Enzyme Class |
2.7.11.1 |
| Molecular Weight |
84429 |
| Protein Length |
753 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a protein = ADP + a phosphoprotein. |
| Localization |
Cell membrane |
| Function (UniProt annotation) |
Serine/threonine-protein kinase (PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). |
| Gene Ontology |
GO:0000165; GO:0000226; GO:0004674; GO:0005524; GO:0005737; GO:0005829; GO:0005886; GO:0006468; GO:0018105; GO:0030010; GO:0030425; GO:0032092; GO:0035331; GO:0035556; GO:0036289; GO:0050321; GO:0070062 |
