| Gene |
PDE4A
|
| Protein Name |
PDE4A_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) |
| Protein Family |
Cyclic nucleotide phosphodiesterase family |
| NCBI Gene ID |
5141
|
| UniProt ID |
P27815
|
| Enzyme Class |
3.1.4.53 |
| Molecular Weight |
98143 |
| Protein Length |
886 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
Adenosine 3' |
| Localization |
Isoform 1: Cytoplasm, perinuclear region.; Isoform 2: Cytoplasm, perinuclear region. Cell projection, ruffle membrane.; Isoform 4: Membrane; Peripheral membrane protein. Note=Isoform 4 has propensity for association with membranes.; Isoform 6: Cytoplasm, perinuclear region.; Isoform 7: Cytoplasm. Membrane. Note=Predominantly cytoplasmic. |
| Function (UniProt annotation) |
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. |
| Gene Ontology |
GO:0004115; GO:0005654; GO:0005829; GO:0005886; GO:0006198; GO:0007165; GO:0007186; GO:0007608; GO:0010738; GO:0016020; GO:0030552; GO:0032587; GO:0035690; GO:0043949; GO:0046872; GO:0048471 |
