| Gene |
NOS3
|
| Protein Name |
NOS3_BOVIN |
| Organism |
Bos taurus (Bovine) |
| Alternative name(s) |
Nitric oxide synthase, endothelial (EC 1.14.13.39) (Constitutive NOS) (cNOS) (EC-NOS) (Endothelial NOS) (eNOS) (NOS type III) (NOSIII) |
| Protein Family |
NOS family |
| NCBI Gene ID |
N/A
|
| UniProt ID |
P29473
|
| Enzyme Class |
1.14.13.39 |
| Molecular Weight |
133287 |
| Protein Length |
1205 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
2 L-arginine + 3 NADPH + 4 O(2) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H(2)O. |
| Localization |
Cell membrane |
| Function (UniProt annotation) |
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. |
| Gene Ontology |
GO:0003958; GO:0004517; GO:0005516; GO:0005634; GO:0005794; GO:0005829; GO:0005856; GO:0005886; GO:0005901; GO:0006527; GO:0006809; GO:0007005; GO:0007263; GO:0007596; GO:0009725; GO:0010181; GO:0012506; GO:0016491; GO:0020037; GO:0031284; GO:0032496; GO:0045776; GO:0046872; GO:0050660; GO:0050661; GO:0071499; GO:1902042; GO:1903038 |
