| Gene |
CDC25B
|
| Protein Name |
MPIP2_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) |
| Protein Family |
MPI phosphatase family |
| NCBI Gene ID |
994
|
| UniProt ID |
P30305
|
| Enzyme Class |
3.1.3.48 |
| Molecular Weight |
64987 |
| Protein Length |
580 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. |
| Localization |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
| Function (UniProt annotation) |
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity. |
| Gene Ontology |
GO:0000086; GO:0000278; GO:0000922; GO:0001556; GO:0004721; GO:0004725; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0006468; GO:0007144; GO:0008284; GO:0010971; GO:0019901; GO:0032467; GO:0045860; GO:0045931; GO:0051301; GO:0110032 |
