| Gene |
DDIT3
|
| Protein Name |
DDIT3_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA damage-inducible protein GADD153) |
| Protein Family |
BZIP family |
| NCBI Gene ID |
1649
|
| UniProt ID |
P35638
|
| Enzyme Class |
- |
| Molecular Weight |
19175 |
| Protein Length |
169 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm Note=Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation. |
| Function (UniProt annotation) |
Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response. |
| Gene Ontology |
GO:0000122; GO:0000976; GO:0000978; GO:0000981; GO:0001077; GO:0001955; GO:0003677; GO:0003700; GO:0003714; GO:0005634; GO:0005654; GO:0005737; GO:0005770; GO:0005829; GO:0006355; GO:0006974; GO:0006983; GO:0006986; GO:0007050; GO:0008134; GO:0008140; GO:0016055; GO:0032757; GO:0032792; GO:0032993; GO:0034976; GO:0035976; GO:0036488; GO:0036499; GO:0036500; GO:0042594; GO:0042789; GO:0042803; GO:0043161; GO:0043433; GO:0043522; GO:0043525; GO:0043620; GO:0044212; GO:0044324; GO:0045454; GO:0045599; GO:0045662; GO:0045892; GO:0045893; GO:0045944; GO:0046982; GO:0051091; GO:0051209; GO:0051259; GO:0051898; GO:0070059; GO:0072655; GO:0090090; GO:0120163; GO:1902237; GO:1903026; GO:1990440; GO:1990442; GO:1990617; GO:1990622; GO:2000016 |
