| Gene |
FLT3
|
| Protein Name |
FLT3_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
2322
|
| UniProt ID |
P36888
|
| Enzyme Class |
2.7.10.1 |
| Molecular Weight |
112903 |
| Protein Length |
993 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. |
| Localization |
Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen. Note=Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation. |
| Function (UniProt annotation) |
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. |
| Gene Ontology |
GO:0000165; GO:0001776; GO:0002318; GO:0002328; GO:0004714; GO:0004888; GO:0004896; GO:0005021; GO:0005088; GO:0005524; GO:0005634; GO:0005737; GO:0005783; GO:0005788; GO:0005829; GO:0005886; GO:0005887; GO:0007169; GO:0008284; GO:0009968; GO:0010243; GO:0014068; GO:0016032; GO:0016303; GO:0018108; GO:0019221; GO:0030097; GO:0030154; GO:0030183; GO:0031100; GO:0035259; GO:0035726; GO:0042531; GO:0042803; GO:0042981; GO:0043066; GO:0043235; GO:0043406; GO:0043410; GO:0043552; GO:0043621; GO:0044877; GO:0046651; GO:0046777; GO:0070374; GO:0071345; GO:0071385; GO:0097028 |
