| Gene |
SREBF1
|
| Protein Name |
SRBP1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Sterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1] |
| Protein Family |
SREBP family |
| NCBI Gene ID |
6720
|
| UniProt ID |
P36956
|
| Enzyme Class |
- |
| Molecular Weight |
121675 |
| Protein Length |
1147 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Endoplasmic reticulum membrane |
| Function (UniProt annotation) |
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). |
| Gene Ontology |
GO:0000122; GO:0000139; GO:0000977; GO:0000981; GO:0001077; GO:0003062; GO:0003677; GO:0003682; GO:0003700; GO:0004879; GO:0005634; GO:0005635; GO:0005654; GO:0005737; GO:0005783; GO:0005789; GO:0005829; GO:0006357; GO:0006629; GO:0007568; GO:0007623; GO:0008047; GO:0008203; GO:0008286; GO:0008610; GO:0009267; GO:0009749; GO:0010867; GO:0012507; GO:0016021; GO:0019217; GO:0019901; GO:0030324; GO:0031065; GO:0031647; GO:0032094; GO:0032526; GO:0032570; GO:0032810; GO:0032991; GO:0033762; GO:0042789; GO:0044877; GO:0045444; GO:0045540; GO:0045542; GO:0045944; GO:0046676; GO:0046983; GO:0051591; GO:0071398; GO:1902895; GO:1903146; GO:1903214 |
