| Gene |
Gata4
|
| Protein Name |
GATA4_RAT |
| Organism |
Rattus norvegicus (Rat) |
| Alternative name(s) |
Transcription factor GATA-4 (DNA-binding protein GATA-GT2) (GATA-binding factor 4) |
| Protein Family |
N/A |
| NCBI Gene ID |
54254
|
| UniProt ID |
P46152
|
| Enzyme Class |
- |
| Molecular Weight |
44597 |
| Protein Length |
440 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus |
| Function (UniProt annotation) |
Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (By similarity). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (By similarity). Required during testicular development (By similarity). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (PubMed:15329343). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (PubMed:15329343). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (By similarity). |
| Gene Ontology |
GO:0000978; GO:0000981; GO:0001077; GO:0001085; GO:0001158; GO:0003180; GO:0003197; GO:0003290; GO:0003677; GO:0003700; GO:0003713; GO:0005634; GO:0006355; GO:0007507; GO:0008134; GO:0008270; GO:0008584; GO:0009612; GO:0009887; GO:0009888; GO:0010507; GO:0016604; GO:0019901; GO:0030513; GO:0033189; GO:0033613; GO:0042493; GO:0043565; GO:0044212; GO:0045893; GO:0045944; GO:0048468; GO:0048646; GO:0051525; GO:0055007; GO:0060290; GO:0060575; GO:0061049; GO:0070410; GO:0071333; GO:0086004; GO:0090575 |
