CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	SLC9A3
Protein Name	SL9A3_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3)
Protein Family	Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
NCBI Gene ID	6550
UniProt ID	P48764
Enzyme Class	-
Molecular Weight	92855
Protein Length	834
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Apical cell membrane
Function (UniProt annotation)	Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient (PubMed:26358773). Plays an important role in signal transduction.
Gene Ontology	GO:0005886; GO:0005903; GO:0006811; GO:0009986; GO:0015385; GO:0015386; GO:0016021; GO:0016324; GO:0030165; GO:0031526; GO:0051453; GO:0070062; GO:0071805; GO:0098719

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
RPS6KA3 (P51812)	Homo sapiens	S663	TMRKRLESFKSTKLG	0.771	0.4652	-	-	-	-	-	-	in-vivo

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found