| Gene |
NR2C2
|
| Protein Name |
NR2C2_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4) |
| Protein Family |
Nuclear hormone receptor family |
| NCBI Gene ID |
7182
|
| UniProt ID |
P49116
|
| Enzyme Class |
- |
| Molecular Weight |
65414 |
| Protein Length |
596 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus |
| Function (UniProt annotation) |
Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. |
| Gene Ontology |
GO:0000977; GO:0000978; GO:0000981; GO:0001077; GO:0001228; GO:0003700; GO:0003707; GO:0003713; GO:0005654; GO:0006355; GO:0006367; GO:0007283; GO:0007399; GO:0008270; GO:0030154; GO:0038023; GO:0043565; GO:0045944; GO:0046982 |
