| Gene |
CSNK1E
|
| Protein Name |
KC1E_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
1.03E+12
|
| UniProt ID |
P49674
|
| Enzyme Class |
2.7.11.1 |
| Molecular Weight |
47315 |
| Protein Length |
416 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a protein = ADP + a phosphoprotein. |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation. |
| Gene Ontology |
GO:0000086; GO:0003723; GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006281; GO:0006468; GO:0006897; GO:0007165; GO:0010389; GO:0018105; GO:0018107; GO:0032091; GO:0032436; GO:0032922; GO:0042752; GO:0060070; GO:0090263; GO:0097711; GO:1903827; GO:1905426; GO:2000052 |
