| Gene |
TSC2
|
| Protein Name |
TSC2_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Tuberin (Tuberous sclerosis 2 protein) |
| Protein Family |
N/A |
| NCBI Gene ID |
7249
|
| UniProt ID |
P49815
|
| Enzyme Class |
- |
| Molecular Weight |
200608 |
| Protein Length |
1807 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes. |
| Function (UniProt annotation) |
In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:15340059). May also play a role in microtubule-mediated protein transport (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). |
| Gene Ontology |
GO:0001843; GO:0005096; GO:0005634; GO:0005737; GO:0005764; GO:0005794; GO:0005829; GO:0006469; GO:0006606; GO:0006897; GO:0007507; GO:0008104; GO:0008285; GO:0014067; GO:0014069; GO:0016020; GO:0016032; GO:0016192; GO:0016239; GO:0019902; GO:0030100; GO:0030178; GO:0031267; GO:0032007; GO:0033596; GO:0042803; GO:0043276; GO:0043491; GO:0046626; GO:0046627; GO:0048009; GO:0048471; GO:0050918; GO:0051056; GO:0051726; GO:0051879; GO:0051898; GO:1901525 |
