| Gene |
Tsc2
|
| Protein Name |
TSC2_RAT |
| Organism |
Rattus norvegicus (Rat) |
| Alternative name(s) |
Tuberin (Tuberous sclerosis 2 protein homolog) |
| Protein Family |
N/A |
| NCBI Gene ID |
24855
|
| UniProt ID |
P49816
|
| Enzyme Class |
- |
| Molecular Weight |
201278 |
| Protein Length |
1809 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
N/A |
| Function (UniProt annotation) |
In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (By similarity). May also play a role in microtubule-mediated protein transport (PubMed:16707451). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (PubMed:9045618). |
| Gene Ontology |
GO:0001933; GO:0005096; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005901; GO:0007165; GO:0007568; GO:0008285; GO:0010719; GO:0010763; GO:0010976; GO:0016242; GO:0019902; GO:0030010; GO:0030030; GO:0030178; GO:0030425; GO:0030426; GO:0032007; GO:0032991; GO:0033596; GO:0034394; GO:0035176; GO:0042995; GO:0043005; GO:0043025; GO:0043231; GO:0043407; GO:0045121; GO:0045184; GO:0045785; GO:0045792; GO:0046627; GO:0046982; GO:0047485; GO:0048147; GO:0048471; GO:0048550; GO:0050680; GO:0050771; GO:0051056; GO:0051260; GO:0051291; GO:0051726; GO:0051898; GO:0060999; GO:0098978; GO:0099175; GO:1905563 |
