| Gene |
Atp6v1a
|
| Protein Name |
VATA_MOUSE |
| Organism |
Mus musculus (Mouse) |
| Alternative name(s) |
V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar proton pump subunit alpha) |
| Protein Family |
ATPase alpha/beta chains family |
| NCBI Gene ID |
11964
|
| UniProt ID |
P50516
|
| Enzyme Class |
7.1.2.2 |
| Molecular Weight |
68326 |
| Protein Length |
617 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + H(2)O + 4 H(+)(Side 1) = ADP + phosphate + 4 H(+)(Side 2). |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity. |
| Gene Ontology |
GO:0005524; GO:0005739; GO:0005774; GO:0005829; GO:0005886; GO:0005902; GO:0006879; GO:0015991; GO:0016324; GO:0033180; GO:0036295; GO:0043209; GO:0046034; GO:0046961 |
