CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	Pde4a
Protein Name	PDE4A_RAT
Organism	Rattus norvegicus (Rat)
Alternative name(s)	cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.53) (DPDE2)
Protein Family	Cyclic nucleotide phosphodiesterase family
NCBI Gene ID	25638
UniProt ID	P54748
Enzyme Class	3.1.4.53
Molecular Weight	93439
Protein Length	844
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	Adenosine 3'
Localization	Cytoplasm, perinuclear region
Function (UniProt annotation)	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Gene Ontology	GO:0004114; GO:0005634; GO:0005737; GO:0005829; GO:0006198; GO:0007165; GO:0042493; GO:0046872; GO:0048471; GO:0050804; GO:0098685

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
Mapkapk2 (P49138)	Mus musculus	S147	SFLYRSDSDYDMSPK	N/A	0.5139	TP	certain	experimental	72 \| 73 \| 9 \| 140 \|	21323643	-	-
MAPKAPK2 (P49137)	Homo sapiens	S147	SFLYRSDSDYDMSPK	N/A	0.5139	-	-	-	-	-	-	In vitro and in vivo

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
rno00230	Purine metabolism

No NCI Nature pathways found