| Gene |
PRPS1
|
| Protein Name |
PRPS1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase I) (PRS-I) |
| Protein Family |
Ribose-phosphate pyrophosphokinase family |
| NCBI Gene ID |
5631
|
| UniProt ID |
P60891
|
| Enzyme Class |
2.7.6.1 |
| Molecular Weight |
34834 |
| Protein Length |
318 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. |
| Localization |
N/A |
| Function (UniProt annotation) |
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. |
| Gene Ontology |
GO:0000287; GO:0002189; GO:0004749; GO:0005524; GO:0005737; GO:0005829; GO:0006015; GO:0006144; GO:0006164; GO:0006221; GO:0007399; GO:0009116; GO:0009156; GO:0009165; GO:0016301; GO:0034418; GO:0042802; GO:0042803; GO:0046101 |
