| Gene |
CXCR4
|
| Protein Name |
CXCR4_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (FB22) (Fusin) (HM89) (LCR1) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Lipopolysaccharide-associated protein 3) (LAP-3) (LPS-associated protein 3) (NPYRL) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184) |
| Protein Family |
G-protein coupled receptor 1 family |
| NCBI Gene ID |
7852
|
| UniProt ID |
P61073
|
| Enzyme Class |
- |
| Molecular Weight |
39746 |
| Protein Length |
352 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cell membrane Cell junction. Early endosome. Late endosome. Lysosome. Note=In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC). |
| Function (UniProt annotation) |
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:10452968, PubMed:28978524, PubMed:18799424). Plays a role in regulation of cell migration, e.g. during wound healing (PubMed:28978524). Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (PubMed:20228059). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity). |
| Gene Ontology |
GO:0000187; GO:0001618; GO:0001666; GO:0002407; GO:0003779; GO:0004930; GO:0005737; GO:0005764; GO:0005769; GO:0005770; GO:0005886; GO:0006915; GO:0006935; GO:0006954; GO:0006955; GO:0007186; GO:0007204; GO:0007411; GO:0007420; GO:0009615; GO:0009897; GO:0009986; GO:0015026; GO:0016021; GO:0016493; GO:0016494; GO:0019064; GO:0019722; GO:0019956; GO:0019957; GO:0022008; GO:0030054; GO:0030260; GO:0031252; GO:0031410; GO:0031625; GO:0032027; GO:0032991; GO:0038147; GO:0038160; GO:0043130; GO:0043217; GO:0048714; GO:0050920; GO:0060326; GO:0070062; GO:0071345; GO:0120162 |
