| Gene |
HIST1H2BC; HIST1H2BE; HIST1H2BF; HIST1H2BG; HIST1H2BI
|
| Protein Name |
H2B1C_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l) |
| Protein Family |
Histone H2B family |
| NCBI Gene ID |
3.02E+23
|
| UniProt ID |
P62807
|
| Enzyme Class |
- |
| Molecular Weight |
13906 |
| Protein Length |
126 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus. Chromosome. |
| Function (UniProt annotation) |
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| Gene Ontology |
GO:0000786; GO:0002227; GO:0003677; GO:0005615; GO:0005634; GO:0005654; GO:0005829; GO:0006334; GO:0016567; GO:0019731; GO:0042802; GO:0046982; GO:0050830; GO:0061844; GO:0070062 |
