| Gene |
Cxcr4
|
| Protein Name |
CXCR4_MOUSE |
| Organism |
Mus musculus (Mouse) |
| Alternative name(s) |
C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (Fusin) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Pre-B-cell-derived chemokine receptor) (PB-CKR) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184) |
| Protein Family |
G-protein coupled receptor 1 family |
| NCBI Gene ID |
12767
|
| UniProt ID |
P70658
|
| Enzyme Class |
- |
| Molecular Weight |
40426 |
| Protein Length |
359 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cell membrane |
| Function (UniProt annotation) |
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:8962122, PubMed:9295051, PubMed:9103415). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation (PubMed:9634237, PubMed:9634238, PubMed:9689100). Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells (PubMed:9634237). Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (PubMed:9634238, PubMed:9689100). |
| Gene Ontology |
GO:0001569; GO:0001667; GO:0001764; GO:0001934; GO:0002064; GO:0003281; GO:0003779; GO:0005737; GO:0005764; GO:0005768; GO:0005769; GO:0005770; GO:0005886; GO:0005911; GO:0006935; GO:0006955; GO:0007186; GO:0007204; GO:0007281; GO:0007399; GO:0007420; GO:0008045; GO:0008144; GO:0008354; GO:0009887; GO:0009897; GO:0009986; GO:0016021; GO:0016477; GO:0016493; GO:0016494; GO:0019722; GO:0019956; GO:0019957; GO:0022008; GO:0022029; GO:0030334; GO:0030335; GO:0030426; GO:0031252; GO:0031410; GO:0031625; GO:0032027; GO:0032991; GO:0035470; GO:0035701; GO:0035904; GO:0038147; GO:0038160; GO:0042098; GO:0043067; GO:0043130; GO:0043217; GO:0045446; GO:0048699; GO:0048714; GO:0050769; GO:0050792; GO:0050920; GO:0050965; GO:0050966; GO:0051924; GO:0060048; GO:0060326; GO:0061154; GO:0061351; GO:0071345; GO:0090280; GO:0120162; GO:1903861; GO:1905322 |
