| Gene |
Kcnj11
|
| Protein Name |
KCJ11_RAT |
| Organism |
Rattus norvegicus (Rat) |
| Alternative name(s) |
ATP-sensitive inward rectifier potassium channel 11 (BIR) (Inward rectifier K(+) channel Kir6.2) (Potassium channel, inwardly rectifying subfamily J member 11) |
| Protein Family |
Inward rectifier-type potassium channel (TC 1.A.2.1) family |
| NCBI Gene ID |
83535
|
| UniProt ID |
P70673
|
| Enzyme Class |
- |
| Molecular Weight |
43608 |
| Protein Length |
390 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Membrane; Multi-pass membrane protein. |
| Function (UniProt annotation) |
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (By similarity). |
| Gene Ontology |
GO:0001669; GO:0002931; GO:0005242; GO:0005524; GO:0005635; GO:0005739; GO:0005768; GO:0005783; GO:0005829; GO:0005886; GO:0006006; GO:0006813; GO:0008022; GO:0008282; GO:0010107; GO:0014704; GO:0015272; GO:0030315; GO:0030506; GO:0030673; GO:0031072; GO:0032355; GO:0033198; GO:0033574; GO:0042383; GO:0042391; GO:0042493; GO:0043025; GO:0043209; GO:0043231; GO:0044325; GO:0046676; GO:0050877; GO:0070852; GO:0071316; GO:0071333; GO:0071356; GO:1903078; GO:2001259 |
