| Gene |
POU5F1
|
| Protein Name |
PO5F1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
POU domain, class 5, transcription factor 1 (Octamer-binding protein 3) (Oct-3) (Octamer-binding protein 4) (Oct-4) (Octamer-binding transcription factor 3) (OTF-3) |
| Protein Family |
POU transcription factor family |
| NCBI Gene ID |
5460
|
| UniProt ID |
Q01860
|
| Enzyme Class |
- |
| Molecular Weight |
38571 |
| Protein Length |
360 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm. Nucleus. Note=Expressed in a diffuse and slightly punctuate pattern. Colocalizes with MAPK8 and MAPK9 in the nucleus. |
| Function (UniProt annotation) |
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. |
| Gene Ontology |
GO:0000122; GO:0000976; GO:0000981; GO:0001227; GO:0001714; GO:0001824; GO:0003130; GO:0003677; GO:0003700; GO:0003723; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0005739; GO:0005829; GO:0006355; GO:0006366; GO:0008134; GO:0009611; GO:0009653; GO:0009786; GO:0010468; GO:0031625; GO:0035019; GO:0035198; GO:0042789; GO:0043565; GO:0044212; GO:0045944; GO:0060391; GO:0060795; GO:0060913; GO:0060965; GO:0090081; GO:0090263; GO:0090308 |
