| Gene |
GFPT1
|
| Protein Name |
GFPT1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 1) (Glutamine:fructose-6-phosphate amidotransferase 1) (GFAT 1) (GFAT1) (Hexosephosphate aminotransferase 1) |
| Protein Family |
N/A |
| NCBI Gene ID |
2673
|
| UniProt ID |
Q06210
|
| Enzyme Class |
2.6.1.16 |
| Molecular Weight |
78806 |
| Protein Length |
699 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate. |
| Localization |
N/A |
| Function (UniProt annotation) |
Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes ARNTL/BMAL1 and CRY1. |
| Gene Ontology |
GO:0004360; GO:0005829; GO:0006002; GO:0006047; GO:0006048; GO:0006112; GO:0006487; GO:0006541; GO:0032922; GO:0036498; GO:0070062; GO:0097367 |
