| Gene |
SOS1
|
| Protein Name |
SOS1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Son of sevenless homolog 1 (SOS-1) |
| Protein Family |
N/A |
| NCBI Gene ID |
6654
|
| UniProt ID |
Q07889
|
| Enzyme Class |
- |
| Molecular Weight |
152464 |
| Protein Length |
1333 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
N/A |
| Function (UniProt annotation) |
Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). |
| Gene Ontology |
GO:0000165; GO:0000786; GO:0001782; GO:0001942; GO:0003209; GO:0003344; GO:0003677; GO:0005085; GO:0005088; GO:0005089; GO:0005096; GO:0005737; GO:0005829; GO:0005886; GO:0007165; GO:0007173; GO:0007186; GO:0007265; GO:0007296; GO:0007411; GO:0008286; GO:0014069; GO:0017124; GO:0019221; GO:0033081; GO:0035023; GO:0035264; GO:0038095; GO:0038128; GO:0042129; GO:0043025; GO:0043065; GO:0045742; GO:0046982; GO:0048011; GO:0048514; GO:0050900; GO:0051056; GO:0051057; GO:0060021; GO:0061029; GO:0061384; GO:1904693; GO:2000973 |
